|
KMID : 1007520100190061673
|
|
Food Science and Biotechnology
2010 Volume.19 No. 6 p.1673 ~ p.1677
|
|
|
Cherry Silver Berry (Elaeagnus multiflora) Extracts Exert Antiinflammatory Effects by Inhibiting COX-2 and Akt Signals in HT-29 Colon Cancer Cells
|
|
Lee Mee-Sook
Lee Yun-Kyoung
Park Ock-Jin
|
|
|
Abstract
|
|
|
|
In this study, the potential of cherry silver berry (Elaeagnus multiflora) as a cancer preventive agent through regulating inflammatory signals including cyclooxygenase- 2 (COX-2) and Akt was examined. Cherry silver berry has reported to exert anti-oxidative, anti-inflammatory, and antiproliferative effects. The extracts from seed and flesh of cherry silver berry were obtained, and analyzed COX-2 and Akt activities in cherry silver berry extract treated HT- 29 colon cancer cells. The results showed that the treatment of seed extracts reduced cell viability at the concentrations above 1,600 mg/mL, effectively reduced COX-2 and p-Akt expression. In addition, the antiinflammatory effects seemed to be related to cancer cell death. Both of seed and flesh extracts inhibited cell growth and induced apoptosis in HT-29 cells. These results suggest that extracts of cherry silver berry may contribute to suppressing cancer growth through its anti-inflammatory and anti-proliferative effects, and natural products used as oriental medicine have the possibility to control tumor cell growth.
|
|
|
KEYWORD
|
|
|
Akt, cyclooxygenase-2, apoptosis, colon cancer, Elaeagnus multiflora
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|